The best in vitro/in vivo models have been established in CORESTEMCHEMON to evaluate the efficacy of new drug candidates or raw materials for health functional foods, and we have extensive practical experience and provide customer-oriented and optimized evaluation services.
Services
Cardiovascular disease
Thrombosis & Hemostasis
Urinary disease
Renal disease
Respiratory disease
CNS disease
Pain killing & Anti-inflammation
Arthritis & Immune disease
Gastrointestinal disease
Metabolic disease
Endocrinopathy
Dermatopathy
Anticancer
Anti bacteria
Liver disease
Biodistribution assessment
ETC
We have various in vitro and in vivo models and research experts for the evaluation of
efficacy of new drug candidates, etc, and provide customer-oriented and optimized
services.
Gene Analysis Center (Biodistribution Assessment Test)
For gene/cell therapeutic agents, quantitative PCR methods are performed to assess the in vivo distribution, engraftment, proliferation, and disappearance of cells for a sufficient period of time after administration of the test article.
A quantitative of test article using real-time PCR to determine the route of administration, dosage, and clinical observation period for clinical trials by evaluating the in vivo disappearance time point after administration of biopharmaceuticals in animals.
ADME Center(Non-Clinical ADME evalution)
ADME is an abbreviation for absorption, distribution, metabolism, and excretion. It is a study that identifies the dynamics of drugs, such as efficacy and duration, mechanism of action, biodistribution, and concentration.
Pharmacokinetics is a study that takes the ADME mechanism as a central research task, and is treated as very important in the stage just before conducting clinical trials in the process of developing new drugs (Pre-Clinical Trial: pre-clinical trial stage).
In vitro ADME
Microsomal stability assay
Plasma protein binding assay
Plasma stability
Rodent, non-rodent pharmacokinetics
Mouse, Rat, beagle, Guinea pig by various routes of administration
compared with IV infusion or bolus(plasma, urine, tissues)
ChemOn Inc